sleeping sickness…

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african trypanosomiasis, sleeping sickness, infectious parasitic disease, carried by tsetse flies, characterized by inflammation, the brain, covering, the brain, meninges, sleeping sickness, two organisms, t, brucei rhodesiense, t, brucei gambiense, severe form, the illness, rhodesiense, after a person is bitten, infected fly, a red, painful swelling develops, site, the fly bite, in chagas disease, from this site, parasite invades the blood stream, causing episodes of fever, headache, sweating, generalized enlargement, the lymph nodes, parasites then invade the central nervous system, rhodesiense, gambiense, where they produce the symptoms typical of sleeping sickness, ultimately the parasites invade the brain, first causing behavioral changes fear, mood swings, followed by headache, fever, weakness, simultaneously, develop myocarditis, death, 6 months from cardiac failure, from rhodesiense infection, gambiense infection, require up to 2 years, symptoms of infection, in the central nervous system appear, gambiense-infected people develop drowsiness, insomnia at night, sleep becomes uncontrollable, the disease progresses, patient becomes comatose, risk factors include living in those parts of africa, disease is found, bitten by tsetse flies, incidence is extremely low, found in travelers, visited, lived in those african areas, swollen red painful nodule at site of inoculation, generalized lymphadenopathy, swollen lymph nodes all over the body, headache, fever, sweating, anxiety, increased sleepiness, insomnia at night, mood changes, drowsiness, uncontrollable urge to sleep, a physical examination, signs of meningoencephalitis, inflammation, the brain, meninges, blood smear, demonstrates motile trypanosomes in blood, lymph node aspiration, demonstrates motile trypanosomes in node material, csf, demonstrates motile trypanosomes in cerebrospinal fluid, low red blood cell count in blood, elevated globulin levels, low albumin levels, elevated esr, antibody, antigen test, medications, treat this disorder, suramin, antrypol, melarsoprol, pentamidine, untreated rhodesiense infection is universally fatal, gambiense infection causes, classic "sleeping sickness" disease, diseases, treated immediately upon diagnosis, easier to treat, blood-borne stage, difficult to treat once meningoencephalitis develops, injury related to falling asleep driving, engaging in similar activities, progressive damage, nervous system, symptoms of this disorder develop, important to begin treatment, pentamidine injections protect against gambiense, have not yet been demonstrated, effective against rhodesiense, insect control measures, prevent the spread of sleeping sickness in areas, disease is endemic.