primary biliary cirrhosis…

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digestive system, bile pathway, pbc, primary biliary cirrhosis, inflammation, irritation, swelling, the bile ducts, the liver resulting in narrowing, obstruction, the flow of bile, obstruction damages liver cells, inflamed bile ducts, the liver in this condition is not known, disease more commonly affects middle-aged women, onset of symptoms is gradual, fatigue, itching skin, the most common first symptom, long-standing bile obstruction is believed to lead to liver cirrhosis, disease associated, autoimmune disorders hypothyroidism, raynaud's, crest syndrome, arthridities, 3 to 15 cases per million people, population each year, itching, jaundice, enlarged liver, abdominal pain, fatty deposits under the skin, soft yellow spots on the eyelid, fatty stools, tests that suggest, confirm the disease, liver biopsy, mitochondrial antibodies, positive in, 95% of cases, tests that reveal liver dysfunction, liver function tests, serum cholesterol, lipoproteins increased, therapy is aimed at relief of symptoms, prevention of complications, cholestyramine, colestipol, reduce the itching by reducing blood levels of bile acids, increasing clearance of bile acids, in the skin, ursodeoxycholic acid, improve clearance of bile, bloodstream, vitamin replacement therapy restores fat-soluble vitamins a, k, d lost in fatty stools, a calcium supplement is indicated, prevent osteomalacia, periodic evaluation, drainage, ercp, endoscopic retrograde cholangiopancreatography, ptc, percutaneous transhepatic cholangiography, episodes of cholangitis necessary, liver transplant, primary biliary cirrhosis, prior to liver failure has been successful, course is variable, condition is untreated, most patients, need a liver transplant after, syears, statistical models, predict the best timing, transplantation, progressive cirrhosis, lead to liver failure, bleeding, malnutrition, renal failure, fluid, electrolyte imbalance, encephalopathy, brain, osteodystrophy, a condition that softens the bones, malabsorption, prolonged itching, the skin develops that is not related to other causes, jaundice, symptoms of cirrhosis develop, vomiting blood, blood, in the stools, confusion, abdominal swelling, jaundice, symptoms that indicate cirrhosis worsening, new symptoms develop.