hemolytic-uremic syndrome, hus…

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male urinary system, hus, hus, disorder marked by kidney failure, hemolytic anemia, thrombocytopenia, platelet deficiency, coagulation defects, variable nervous system signs, common in children, frequently occurs after a gastrointestinal, enteric, infection, a specific e. coli bacteria, escherichia coli o157, h7, has also been associated, enteric infections, shigella, salmonella, non-enteric infections, hus, once relatively rare, increasing in children, the most common cause of acute kidney failure in children, several large outbreaks in 1992, 1993 were attributed to undercooked hamburger contaminated, e. coli, association, supermarket hamburger has new labeling, new temperature guidelines, hamburger cooked at fast-food chains, restaurants, hus is more complicated in adults, similar to another disease, thrombotic thrombocytopenic purpura, ttp, predisposing risk factors, not known, hus occasionally occurs in association, a variety of other diseases, infections, 1 in 10,000 people get it, hus often begins, vomiting, diarrhea, bloody, a week, patient develops weakness, irritability, urine output decreases dramatically, cease, red blood cells, destroyed, a process, hemolysis, patient rapidly becomes anemic, pale, early symptoms, fever, vomiting, diarrhea, blood, in the stools, irritability, weakness, lethargy, later developing symptoms, low urine output, no urine output, paleness, bruising, skin rash that looks, fine red spots, petechiae, yellowish coloration, skin, jaundice, decreased consciousness, seizures, rare, a physical examination, an enlarged liver, spleen, variable, abnormal nervous system changes, laboratory evidence of hemolytic anemia, acute renal failure, a complete blood count, cbc, might show, decreased platelet count, thrombocytopenia, rupture of red blood cells, anemia from loss of red blood cells, hemolytic anemia, elevated white blood count, coagulation studies pt, ptt normal, abnormal, blood chemistry chem-20 shows abnormalities, bun is elevated, creatinine is elevated, free hemoglobin is elevated, a urinalysis demonstrates, blood, in the urine, protein, in the urine, a urine protein test, show the amount, protein, in the urine, tests, stool culture positive, specific type of e. coli, kidney biopsy shows diagnostic changes, serious complicating illness in both children, adults, death, treatment is supportive, transfusions of packed red cells, platelets, kidney dialysis indicated, medications, prescribed include corticosteroids, aspirin, plasmapheresis, plasma exchange, passage, the plasma, a filter, its role is not completely clear, in plasmapharesis, blood plasma, portion, does not contain cells, does contain antibodies, removed, replaced, fresh, donated, plasma, filtered to remove antibodies, circulation, 60% of individuals receiving treatment, recover, outcome is better in children, chronic, relapsing hus, acute kidney failure, chronic kidney failure, uremia, accumulation of nitrogen-containing wastes, symptoms of hus develop, decreased consciousness, blood, in the stool, absent urine output indicate an emergency situation, have experienced an episode of hus, urine output decreases, new symptoms develop, known cause, e. coli in hamburger, ground meats, prevented by adequate cooking, unrecognized causes, not be preventable at this time.