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sulfonylurea antidiabetic agents, also known as sulfonylureas, treat a certain type, diabetes mellitus, sugar diabetes, type 2 diabetes, when you have type 2 diabetes, insulin is still being produced by my pancreas, sometimes the amount, insulin you produce may not be enough, body may not be using it properly and you may still need more, sulfonylureas work by causing my pancreas to release more insulin into the blood stream, all, the cells, in my body need insulin to help turn the food you eat into energy, this is done by using sugar, glucose, blood as quick energy, the sugar, stored, form, fats, sugars, proteins for use later, for energy between meals, sometimes insulin that is being produced by the body is not able to help sugar get inside the body's cells, sulfonylureas help insulin get into the cells where it can work properly to lower blood sugar, in this way, sulfonylureas will help lower blood sugar and help restore the way you use food to make energy, many people with type 2 diabetes can control their blood sugar level with diet, diet and exercise alone, following a diabetes diet plan and exercising will always be important with any type, diabetes, to work properly, sulfonylurea you use, balanced against the amount and type, food you eat, amount, exercise you do, change my diet, exercise, both, will want to test my blood sugar level so that it does not drop too low, hypoglycemia, rise too high, hyperglycemia, health care professional will teach you what to do if this happens, sometimes patients with type 2 diabetes might need to change to treatment with insulin for a short period, time during pregnancy, for a serious medical condition, diabetic coma; ketoacidosis; severe injury, burn, infection, major surgery, in these conditions, insulin and blood sugar can change fast and blood sugar can be best controlled with insulin instead, a sulfonylurea, at some point, a sulfonylurea may stop working as well, blood sugar level will go up, will need to know if this happens and what to do, taking more, a physician may change, another sulfonylurea, inject small doses, insulin, take another oral antidiabetic medicine, metformin along with my sulfonylurea to help the insulin you make work better, that does not bring down the amount, sugar, in my blood, consult doctor before you stop taking the oral antidiabetic agents and begin receiving only insulin injections, chlorpropamide, oral antidiabetic medicines do not help diabetic patients who have type 1 diabetes because these patients cannot produce, release insulin from their pancreas gland, their blood sugar is best controlled by insulin injections, sulfonylureas are available only with a physician's prescription, dosage forms, oral, acetohexamide, tablets, chlorpropamide, tablets, gliclazide, tablets, glimepiride, tablets, glipizide, tablets, extended-release tablets, glyburide, tablets, micronized tablets, tolazamide, tablets, tolbutamide, tablets, for sulfonylurea medicines, allergic reaction to sulfonylureas, to sulfonamide-type, sulfa, thiazide diuretics, a certain type, water pill, allergic to any other substances, foods, preservatives, dyes, sulfonylureas are rarely used during pregnancy, insulin you need changes during and after pregnancy, reason, easier to control my blood sugar using injections, insulin, rather than with the use, sulfonylureas, close control, blood sugar can reduce my chance, having high blood sugar during the pregnancy, baby gaining too much weight, having birth defects , be sure to tell a physician if you plan to become pregnant, think you are pregnant, insulin is not available, cannot be used and sulfonylureas are used during pregnancy, should be stopped at least 2 weeks before the delivery date, one month before for chlorpropamide and glipizide, glimepiride should not be used at all during pregnancy, lowering, blood sugar can occur as a rebound effect at delivery and for several days following birth and will be watched closely by my health care professionals, when breast-feeding , chlorpropamide and tolbutamide pass into human breast milk and glimepiride passes into the milk, rats, chlorpropamide is not recommended in nursing mothers, tolbutamide has been used, nursing mothers should not take glimepiride, not known if other sulfonylureas pass into breast milk, thinking about breast-feeding , children there is little information about the use, sulfonylureas in children, type 2 diabetes is unusual in this age group, some elderly patients, more sensitive than younger adults to the effects, sulfonylureas, especially when more than one antidiabetic medicine is being taken, other medicines that affect blood sugar are also being taken, this may increase my chance, developing low blood sugar during treatment, furthermore, the first signs, low, high blood sugar are not easily seen, do not occur at all in older patients, this may increase the chance, low blood sugar developing during treatment, elderly patients who take chlorpropamide are more likely to hold too much body water, an interaction might occur, change the dose, do not take any other medicine, prescribed, approved by a physician, when you are taking sulfonylurea antidiabetic drugs, health care professionals, alcohol, when low blood sugar occurs, can last longer than usual if more than a small amount, alcohol is taken, especially on an empty stomach, small amounts, alcohol at mealtime usually do not cause problems with my blood sugar, a redness, flushing, face, arms, neck that can be uncomfortable, occur with most, the sulfonylureas, is most likely to occur with chlorpropamide and has occurred up to 12 hours after alcohol was taken during chlorpropamide use, anticoagulants, blood thinners, the effect, the blood thinner, the antidiabetic medicine, decreased if the two medicines are used together, aspirin, other salicylates, azole antifungals, miconazole, monistat i.v, fluconazole, diflucan, chloramphenicol, chloromycetin, cimetidine, tagamet, fluoroquinolones, ciprofloxacin, cipro, enoxacin, penetrex, lomefloxacin, maxaquin, norfloxacin, noroxin, ofloxacin, floxin, quinidine, quinidex, quinine, ranitidine, zantac, may increase the chances, low blood sugar , asparaginase, elspar, corticosteroids, cortisone-like medicine, lithium, lithonate, thiazide diuretics, dyazide, may increase the chances, high blood sugar , asthma medicines, cough, cold medicines, hay fever, allergy medicines, nonprescription, over-the-counter] products, can affect the control, blood sugar, beta-adrenergic blocking agents, acebutolol, sectral, atenolol, tenormin, betaxolol, kerlone, bisoprolol, zebeta, carteolol, cartrol, labetalol, normodyne, metoprolol, lopressor, nadolol, corgard, oxprenolol, trasicor, penbutolol, levatol, pindolol, visken, propranolol, inderal, sotalol, betapace, timolol, blocadren, beta-adrenergic blocking agents may increase the chance that high, low blood sugar can occur, can hide symptoms, low blood sugar , fast heartbeat, this, a person with diabetes might not recognize that he, she has low blood sugar and might not take immediate steps to treat it, beta-adrenergic blocking agents can also cause low blood sugar to last longer than usual, cyclosporine, sandimmune, sulfonylureas can increase the effects, cyclosporine, guanethidine, ismelin, monoamine oxidase, mao, inhibitor activity, isocarboxazid, marplan, isocarboxazid, marplan, phenelzine, nardil, procarbazine, matulane, selegiline, eldepryl, tranylcypromine, parnate, taking a sulfonylurea, within 2 weeks, may increase the chances, low blood sugar occurring, octreotide, sandostatin, pentamidine, pentam, with sulfonylureas may increase the chance, high, low blood sugar occurring other medical problems, the sulfonylurea antidiabetic medicines, any other medical problems, acid, blood, acidosis, burns, severe, diabetic coma, fever, high, injury, severe, ketones, blood, diabetic ketoacidosis, surgery, major, any other condition in which insulin needs change rapidly, insulin, needed temporarily to control diabetes in patients with these conditions because changes in blood sugar may occur rapidly and without much warning; also, blood sugar may need, tested more often, diarrhea, continuing, female hormone changes for some women, during puberty, menstruation, infection, severe, mental stress, severe, overactive adrenal gland, not properly controlled, problems with intestines, severe, slow stomach emptying, vomiting, continuing, any other condition that causes severe blood sugar changes, insulin, needed temporarily to control diabetes mellitus in patients with these conditions because changes in blood sugar may occur rapidly and without much warning; also, blood sugar may need, tested more often, heart disease , chlorpropamide, tolbutamide causes some patients to retain, more body water than usual, heart disease , worsened by this extra body water, kidney disease , liver disease , blood sugar, decreased, partly, slower removal, sulfonylurea from the body; this may change the amount, sulfonylurea you need, overactive thyroid, not properly controlled, underactive thyroid, not properly controlled, blood sugar, decreased, partly because the medicine, removed from the body too fast, too slow, until my thyroid condition is controlled, sulfonylurea you need may change, blood sugar may need, tested more often, underactive adrenal gland, not properly controlled, underactive pituitary gland, not properly controlled, undernourished condition, weakened physical condition, any other condition that causes low blood sugar , patients with these conditions, more likely to develop low blood sugar while taking sulfonylureas, use this medicine, directed, feel well and do not notice any signs, high blood sugar , and do not take it more often, serious side effects, remember that this medicine will not cure my diabetes, it does help control it, must continue, take it as directed if you expect to lower my blood sugar and keep it low, take an antidiabetic medicine for the rest, life, high blood sugar is not treated, it can cause serious problems, heart failure , blood vessel disease, eye disease, kidney disease , a physician will give you instructions about diet, exercise, test my blood sugar levels, adjust my dose when you are sick, diet, the daily number, calories, meal plan should be adjusted by a physician, a registered dietitian to help you reach and maintain a healthy body weight, regular meals and snacks are arranged to meet the energy needs, body at different times, the day, follow my meal plan carefully, exercise, ask a physician what kind, exercise to do, the best time to do it, how much you should do each day, blood tests, this is the best way to tell whether my diabetes is being controlled properly, blood sugar testing helps you, health care team adjust the dose, meal plan, exercise schedule, sick days, when you become sick with a cold, fever, the flu, need, take my usual dose, sulfonylurea, feel too ill to eat, this is especially true, nausea, vomiting, diarrhea, infection usually increases my need to produce more insulin, sometimes you may need, switched from my sulfonylurea to insulin for a short period, sick to properly control blood sugar, call a physician for specific instructions.continue taking my sulfonylurea and try to stay on my regular meal plan, trouble eating solid food, drink fruit juices, nondiet soft drinks, clear soups, eat small amounts, bland foods, a dietitian, health care professional can give you a list, foods, amounts to use for sick days.test my blood sugar level at least every 4 hours, awake and check my urine for ketones, ketones are present, call a physician at once, severe, prolonged vomiting, even when you start feeling better, let a physician know how you are doing, for patients taking glipizide extended-release tablets, swallow the tablet whole, without breaking, crushing, chewing it, may sometimes notice what looks like a tablet, in my stool, do not worry, after you swallow the tablet, tablet is absorbed inside my body, then the tablet passes into my stool without changing its shape, the medicine has entered my body and will work properly, will be different for different patients, follow a physician's orders, the directions on the label, the average doses, dose is different, the number, tablets, take depends on the strength, the number, doses you take each day, the time allowed between doses, time you take the medicine depend on the amount, sugar, in my blood, urine, for acetohexamide, for oral, dosage form, tablets, for treating type 2 diabetes, 250 milligrams, some elderly people may need a lower dose at, then, a physician may change my dose a little at a time, the dose is usually not more than 1.5 grams a day, dose is 1 gram, more, the dose is usually divided into two doses, doses are taken before the morning and evening meals, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for chlorpropamide, for oral, dosage form, tablets, for treating type 2 diabetes, 250 milligrams, some elderly people may need a lower dose, 100 to 125 mg a day at, then, a physician may change my dose a little at a time, the dose is usually not more than 750 mg a day, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for gliclazide, for oral, dosage form, tablets, for treating type 2 diabetes, 80 milligrams, a day with a meal as a single dose, 160 to 320 mg divided into two doses taken with the morning and evening meals, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for glimepiride, for oral, dosage form, tablets, for treating type 2 diabetes, glimepiride alone: at, 1 to 2 milligrams, once a day with breakfast, the first main meal, the dose then, increased by a physician based on my blood sugar level, glimepiride with metformin: the usual dose is 8 mg once a day with breakfast, the first main meal, glimepiride with insulin: the usual dose is 8 mg once a day with breakfast, the first main meal, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for glipizide, for oral, dosage form, tablets, for treating type 2 diabetes, 5 milligrams, some elderly people may need a lower dose, 2.5 mg a day at, then, a physician may change my dose a little at a time, the dose is usually not more than 40 mg a day, dose is 15 mg, more, the dose is usually divided into two doses, doses are taken thirty minutes before the morning and evening meals, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for oral, dosage form, extended-release tablets, for treating type 2 diabetes, 5 mg once a day with breakfast, then, a physician may change my dose a little at a time, the dose is usually not more than 20 mg a day, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for glyburide, for oral, dosage form, nonmicronized tablets, for treating type 2 diabetes, 2.5 to 5 milligrams, some elderly people may need a lower dose, 1.25 to 2.5 mg a day at, then, a physician may change my dose a little at a time, the dose is usually not more than 20 mg a day, dose is 10 mg, more, the dose, divided into two doses, doses are taken with the morning and evening meals, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for oral, dosage form, micronized tablets, for treating type 2 diabetes, 1.5 to 3 mg a day, some elderly people may need a low dose, 0.75 to 3 mg a day at, then, a physician may change my dose a little at a time, the dose is usually not more than 12 mg a day, dose is 6 mg, more, the dose is usually divided into two doses, doses are taken with the morning and evening meals, a single dose is taken with breakfast, with the first meal, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for tolazamide, for oral, dosage form, tablets, for treating type 2 diabetes, 100 to 250 milligrams, then, a physician may change my dose a little at a time, the dose is usually not more than 1 gram a day, dose is 500 mg, more, the dose is usually divided into two doses, doses are taken with the morning and evening meals, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, for tolbutamide, for oral, dosage form, tablets, for treating type 2 diabetes, 1000 to 2000 milligrams, some elderly people may need lower doses to start, the dose is usually divided into two doses, doses are taken before the morning and evening meals, a physician may change my dose a little at a time, the dose is usually not more than 3000 mg a day, diabetes treated with this medicine is rare in children, a child needs this medicine, the dose would have, determined by the doctor, if i miss a dose, almost time for my next dose, skip the missed dose, back to my regular dosing schedule, do not double doses, keep out of a child's reach, store away from heat and direct light, in other damp places, heat, moisture, the medicine to break down, do not keep outdated medicine, medicine no longer needed, discarded medicine is out of a child's reach, precautions, know the side effects, progress at regular visits, especially during the first few weeks, take this medicine, very important to follow carefully any instructions from my health care team about, alcohol, drinking alcohol, severe low blood sugar , discuss this with my health care team, tobacco, been smoking for a long time and suddenly stop, dosage, sulfonylurea may need, reduced, decide to quit, do not take other medicines unless they, discussed with a physician, this especially includes nonprescription medicines, aspirin, medicines for appetite control, asthma, colds, cough, hay fever, sinus problems, counseling, other family members need to learn, prevent side effects, help with side effects, patient if they occur, patients with diabetes, especially teenagers, may need special counseling about sulfonylurea, insulin dosing changes that might occur, lifestyle changes, changes in exercise and diet, furthermore, counseling on contraception and pregnancy, the problems that can occur in women with diabetes who become pregnant, travel, carry a recent prescription, medical history, be prepared for an emergency as you would normally, make allowances for changing time zones, keep my meal times as close as possible to my usual meal times, protecting skin from sunlight, sulfonylureas can make you more sensitive to the sun, sunblock products that have a skin protection factor, spf, at least 15 on my skin and lips can help to prevent sunburn , a sunlamp, tanning bed, booth, emergency, a time when you need emergency help for a problem caused by my diabetes, need, prepared for these emergencies, a good idea to, wear a medical identification, i.d, bracelet, neck chain at all times, carry an i.d, card, in my wallet, purse that says, have diabetes and a list, all, keep some kind, quick-acting sugar handy to treat low blood sugar , a glucagon kit and a syringe and needle available in case severe low blood sugar occurs, check and replace any expired kits regularly, too much, a sulfonylurea can cause low blood sugar , hypoglycemia, symptoms, low blood sugar , treated before they lead to unconsciousness, passing out, different people may feel different symptoms, low blood sugar , learn which symptoms, low blood sugar you usually have so, can treat it quickly, symptoms, low blood sugar can include: anxious feeling, behavior change similar to being drunk, blurred vision , cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness , excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, unusual tiredness , weakness, low blood sugar may develop quickly and may result from, delaying, missing a scheduled meal, snack, exercising more than usual, drinking a significant amount, alcohol, taking certain medicines, taking too high a dose, sulfonylurea, using insulin, using too much insulin, sickness, especially with vomiting, diarrhea, know what to do if symptoms, low blood sugar occur, eating some form, quick-acting sugar when symptoms, low blood sugar first appear will usually prevent them from getting worse.good sources, sugar, glucose tablets, gel, fruit juice, nondiet soft drink, 4 to 6 ounces, one-half cup, corn syrup, honey, 1 tablespoon, sugar cubes, 6 one-half-inch sized, table sugar, dissolved in water, chocolate because its fat slows down the sugar entering the bloodstream, a snack is not scheduled for an hour, more you should also eat a light snack, crackers, a half sandwich, drink an 8-ounce glass, milk, glucagon is used in emergency situations, unconsciousness, a glucagon kit available, along with a syringe and needle, know, prepare and use it, members, household also should know how and when to use it, high blood sugar , hyperglycemia, is another problem related to uncontrolled diabetes, any symptoms, high blood sugar , contact my health care team, high blood sugar is not treated, severe hyperglycemia can occur, leading to ketoacidosis, diabetic coma, symptoms, high blood sugar appear more slowly than those, low blood sugar , symptoms can include: blurred vision; drowsiness; dry mouth; flushed and dry skin; fruit-like breath odor; increased urination; loss, appetite; stomachache, nausea, vomiting; tiredness; troubled breathing, rapid and deep, and unusual thirst, symptoms, severe high blood sugar , ketoacidosis, diabetic coma, that need immediate hospitalization include: flushed dry skin, fruit-like breath odor, ketones in urine, passing out, troubled breathing, rapid and deep, high blood sugar symptoms may occur if you, a fever, diarrhea, an infection, using insulin, do not take enough insulin, skip a dose, insulin, do not exercise as much as usual, overeat, do not follow my meal plan, know what to do if high blood sugar occurs, a physician may recommend changes, in my sulfonylurea dose, meal plan to avoid high blood sugar , symptoms, high blood sugar , corrected before they progress to more serious conditions, check with a physician often to make sure you are controlling my blood sugar, do not change the dose, medicine without checking with a physician, a physician might discuss the following with you, decreasing my dose for a short time for special needs, when you cannot exercise as you normally do, increasing my dose when you plan to eat an unusually large dinner, holidays, this type, increase is, an anticipatory dose, delaying a meal if my blood sugar is over 200 mg/dl to allow time for my blood sugar to go down, an extra dose, an injection, insulin, needed if my blood sugar does not come down shortly, not exercising if my blood sugar is over 240 mg/dl and reporting this to a physician immediately, being hospitalized if ketoacidosis, diabetic coma occurs with a possible change, side effects, the use, sulfonylurea antidiabetic agents has been reported, not proven in all studies, to increase the risk, death from heart and blood vessel disease, patients with diabetes are already more likely to have these problems if they do not control their blood sugar, some sulfonylureas, glyburide and gliclazide, can have a positive effect on heart and blood vessel disease, important to know that problems can occur, also not known if other sulfonylureas, particularly tolbutamide, help to cause these problems, known that if blood sugar is not controlled, such problems can occur, along with their needed effects, sulfonylureas, some unwanted effects, side effects may occur, may need medical attention, check with a physician immediately, side effects occur, convulsions, seizures, unconsciousness, side effects occur, low blood sugar , anxious feeling, behavior change similar to being drunk, blurred vision , cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness , excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, unusual tiredness , weakness, unusual weight gain, peeling, skin, skin redness, itching, rash, chest pain , chills, coughing up blood, dark urine, fever, fluid-filled skin blisters, general feeling, illness, increased amounts, sputum, phlegm, increased sweating, light-colored stools, pale skin, sensitivity to the sun, shortness of breath, sore throat, thinning, the skin, unusual bleeding, bruising, unusual tiredness , weakness, yellow eyes, skin, side effects may go away during treatment, body adjusts to the medicine, side effects continue, bothersome, changes in sense, taste, constipation, diarrhea, dizziness , increased amount, urine, more frequent urination, heartburn, decreased appetite, passing, gas, stomach pain, fullness, discomfort, vomiting, difficulty in focusing the eyes, increased sensitivity, skin to sun, for patients taking chlorpropamide, tolbutamide, rarely, some patients who take chlorpropamide may retain, more body water than usual, this happens even less often with tolbutamide, signs occur, depression, swelling, puffiness, face, ankles, hands, other side effects, additional information once a medicine has been approved for marketing for a certain use, experience may show, also useful for other medical problems, this use is not included in product labeling, chlorpropamide is used in certain patients with the following medical condition, diabetes insipidus, water diabetes, for water diabetes, the advice listed above that relates to diet for patients with sugar diabetes does not apply, the advice about hypoglycemia, low blood sugar , does apply, call a physician right away if you feel, the symptoms described, other than, information, there is no additional information relating to its, side effects, use, brand names some commonly used brand names are, amaryl, diabeta, diabinese, dymelor, glucotrol, glucotrol xl, glynase prestab, micronase, orinase, tolinase, apo-chlorpropamide, apo-glyburide, apo-tolbutamide, diabeta, diabinese, diamicron, dimelor, euglucon, gen-glybe, med glybe, novo-butamide, novo-glyburide, novo-propamide, nu-glyburide, orinase,